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Publications:

Asterisks (**) denote an undergraduate co-author.

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Keen EM, **True EJ, Summers AR, Smith EC, Brew J, Grandjean Lapierre S. 2022. High-throughput digital cough recording on a university campus: A SARS-CoV-2-negative curated open database and operational template for acoustic screening of respiratory diseases. Digital Health. 8: 1-6.

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Barrett CT, Neal HE, Edmonds K, Zamora JLR, Moncman CL, Popa A, Smith EC, Webb SR, Dutch RE. 2021. Analysis of Hendra Virus Fusion Protein N-Terminal Transmembrane Residues. Viruses. 13(12):2353.

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McDarmont SL, **Jones MH, McMillen CD, Smith EC, Pienkos JA, Joslin EE. 2021. Synthesis, characterization, X-ray crystallography analysis and cell viability study of (η6-p-cymene)Ru(NH2R)X2 (X = Cl, Br) derivatives. Polyhedron. 200: 115130.

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Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. 2018. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) Is mediated by the viral polymerase and the proofreading exoribonuclease. mBio. 9(2):e00221-18. 

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Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR. 2017. Murine hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity. J Virol. 92(1):e01531-17. 

 

Graepel KW, Lu X, Case JB, Sexton NR, Smith EC*, Denison MR*. 2017. Proofreading-deficient coronaviruses adapt for increased fitness over long-term passage without reversion of exoribonuclease-inactivating mutations. mBio. 8(6):e01503-17. (*co-corresponding authors) 

 

Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. 2017. In situ tagged nsp15 reveals interactions with coronavirus replication/transcription complex-associated proteins. mBio. 8(1):e02320-16. 

 

Mounce B, Cesaro T, Moratorio G, Hooikaas PJ, Yakovleva A, Werneke S, Smith EC, Poirier E, Simon-Loriere E, Prot M, Tamietti C, Vitry S, Volle R, Khou C,  Freniel MP, Sakuntabhai A, Delpeyroux F, Pardigon N, Flamand M, Barba-Spaeth G, Lafon M, Denison M, Albert M, and Vignuzzi M. 2016. Inhibition of polyamine biosynthesis is a broad-spectrum strategy against RNA viruses. J Virol. 90(21):9683-92. 

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Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen O, Denison MR. 2016. Homology-based identification of a mutation in the coronavirus RNA-dependent RNA polymerase that confers resistance to multiple mutagens. J Virol. 90(16):7415-28. 

 

Mainou BA, Ashrook AW, Smith EC, Dorset D, Denison MR, Dermody TS. 2015. Serotonin receptor agonist 5-nonyloxytryptamine alters the kinetics of reovirus cell entry. J Virol. 89(17):8701-12.

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Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR. 2015. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. J Virol. 89(12):6418-26. 

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Freeman MC, **Peek CT, Becker MM, Smith EC, Denison MR. 2014. Coronaviruses induce entry-independent, continuous macropinocytosis. mBio. 5(4):e01340-14. 

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Smith EC, Smith SE, Carter JR, Webb SR, Gibson K, Hellman LM, Fried MG, Dutch RE. 2013. Trimeric transmembrane domain interactions in paramyxovirus fusion proteins: roles in protein folding, stability, and function. J Biol Chem. 288(50):35726-35. 

 

​Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR. 2013. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.  PLOS Path. 9(8):e1003565. 

  • (Highlighted in: Hofer U. 2013. Nat Rev Microbiol. Sep 10.) 

 

Smith EC, Gregory SM, Tamm LK, Creamer TP, Dutch RE. 2012. Role of sequence and structure of the Hendra fusion protein fusion peptide in membrane fusion. J Biol Chem. 287(35):30035-48.

 

​Smith EC, **Culler MR, Hellman LM, Fried MG, Creamer TP, Dutch RE. 2012. Beyond anchoring: the expanding role of the Hendra virus F protein transmembrane domain in protein folding, stability and function.  J Virol.  86(6):3003-13.

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Smith EC and Dutch RE. 2010. Side chain packing below the fusion peptide strongly modulates triggering of the Hendra F protein. J Virol. 84(20):10928-32. 

 

​Wurth MA, Schowalter RM, Smith EC, Moncman CL, Dutch RE, McCann RO. 2010. The actin cytoskeleton inhibits pore expansion during PIV5 fusion protein-promoted cell-cell fusion. Virology. 404(1):117-26.

 

​Whitman SD, Smith EC, Dutch RE. 2009. Differential rates of protein folding and cellular trafficking for the Hendra virus F and G proteins: implications for F-G complex formation. J Virol. 83(17):8998-9001.

RESEARCH ARTICLES

RESEARCH ARTICLES

REVIEW ARTICLES

 

Smith EC. 2017. The not-so-infinite malleability of RNA viruses: viral and cellular determinants of RNA virus mutation rates. PLoS Path. 13(4):e1006254. 

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Smith EC, Sexton NR, Denison MR. 2014. Thinking outside the triangle: replication fidelity of the largest RNA viruses. Ann Rev of Virol. 1: 111-132. 

 

Smith EC and Denison MR. 2013. Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity. PLoS Path. 9(12):e1003760.

 

Smith EC and Denison MR. 2012. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Curr Opin Virol. 2(5):519-524. 

 

Zhao C, Smith EC, Whiteheart SW. 2012. Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF). Biochim Biophys Acta. 1823(1):159-71. 

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Smith EC, Popa A, Chang A, Masante C, Dutch RE. 2009. Viral entry mechanisms: the increasing diversity of paramyxovirus entry. FEBS J. 276(24):7217-27. 

BOOK CHAPTERS 

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Smith EC and Dutch RE. 2018. Chapter 2: Proteolytic activation of paramyxovirus and pneumoviruses, p. 27-45. In Böttcher-Friebertshäuer E, Garten W, and Klenk HD (ed) Activation of viruses by host proteases, 1st ed. Springer, Cham, Switzerland. (ISBN: 9783319754734)

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Becker MM, Smith EC, Denison MR. 2016. Chapter 12: Emerging viral infections, â€‹p. 329-365. In Weaver SC, Denison MR, Roossinck M, Vignuzzi M (ed), Virus Evolution: Current Research and Future Directions, 1st ed. Caister Academic Press, Norfolk, UK. (ISBN: 9781910190234)

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Melikyan GB, Smith EC, Dutch RE.  2012. 5.15 Mechanisms of enveloped virus entry by membrane fusion, p. 290-311. In Egelman EH (ed), Comprehensive Biophysics, 1st ed. Academic Press, Cambridge, UK. (ISBN: 9780123749208)

 

Schowalter RM, Smith EC, Dutch RE.  2010. Chapter 13: Attachment and entry: viral cell fusion, p. 243-260. In Agbandje-McKenna M, McKenna R (ed), Structural Virology, 1st ed. Royal Society of Chemistry, Cambridge, UK. (ISBN: 9780854041718)

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